Saturday, 8 May 2021

Darkness into Light

 I've had a pretty good pandemic: 

  • retired in a nick of time to avoid having to teach by Zoom;
  • have a hella big garden up behind the house; 
  • had a Brexit fusilli mountain, so didn't need to shop
  • Bobby-no-pals
  • gorra Vax-1
But I appreciate that others are less fortunate, at least partly because covidization has closed down a bunch of social and medical services. Not that we were ever much good with handling mental health in Ireland. Plenty of cash for organ-transplants and hip-replacements; much less for The Black Dog. Since 2006 Pieta House has been trying to fill some of the suicide prevention gaps for which we-the-taxpayer seem unwilling to pony up the cash. They have a network of 200 therapists and bereavement counsellors across the country. Note: those left behind need as much help as the unfortunates who can't take any more and Go. Lithium doesn't work for everybody and therapy takes time, and therefore money. Advocacy is important and a good image helps a lot: the golden lad Bressie personalized his mental health issues as Jeffrey and used his platform to bring these issues into the light.

Pieta House had a cunning plan in 2009 when they launched Darkness Into  Light  with a 5km dawn-greeting walk in the Phoenix Park. 400 people turned up. Today's event Today is hoping to involve 200,000 people worldwide and raise €5,000,000. Today they were a little shy on numbers but [€6,345,852] cup runneth over for payola.  You've missed the dawn but it's not too late to contribute! #darknessintolight2021   The Beloved is more capable of forward planning than me, so she sent the cash in good time, and we've got the tea-shirts; and importantly it's been on the Kitchen Kalendar [R] for a month. We got the times of twilight

  • 04:06 nautical twilight
  • 05:03 civil twilight
  • 05:41 sunrise 60° NE
and we were All Set to trek up the hill and watch the sunrise from St Fursey's Altar. Friday the Seventh would have been a perfick day for such a venture but we're both institutionalised and must do it when told. However, when we were startled awake by alarums at 0400hrs we could hear the rain hosing down outside; and Met Eireann said [L] it wasn't about to let up any time soon. Pieta will be served nothing having Darby O'Bob and Joan ní Salann get soaked to the bone while viewing a sunrise that ain't gonna happen this morning in Ireland. Tomorrow!

Friday, 7 May 2021

Throwaway tech

Humours! Since Hippocrates and Galen, doctors have been tuning in to the fluid balance of the human body. Those ancients and 1,000 years of their followers recognised

  • Black bile - μέλαινα χολή, melaina chole
  • Yellow bile - ξανθη χολή, xanthe chole
  • Phlegm - φλέγμα, phlegma
  • Blood - αἷμα, haima

From which we derive the words for character traits like Melancholy, Phlegmatic and Sanguine. Nobody now believes that depression is due to the spleen making an excess of black bile but the principle did put doctors onto the idea of checking bodily out-puts. If you have experienced a lot of snotty kids in surgery, you can tell from the colour and smell when an excess of rhinovirus has been superseded by a more threatening bacterial infection. In the Netherlands toilets are designed so that user can easily scrutinize the stool before flushing - which is handy for getting on top of another pinworm infestation. It is a rare visit to your medico that doesn't involve a urine sample.

In the old days, the doctor was likely to dip the tip his [sic in the old days] pinkie in the sample bottle and taste it. We have a mighty set of over-lapping, complementary physiological mechanisms for controlling the amount of circulating glucose. Waste not, want not: glucose is the primary currency for energy in the body and without a source of energy cells are quickly dead. The normal interplay between insulin and glucagon scoops up excess glucose before the kidney gets a chance to dump any. You're likely in trouble with sweet pee [Lathyrus odoratus - not].

You may have noticed that your doctor doesn't do the finger thing! They rather shake one out from their vial of 100x Multistix and dip that instead. That gives a more or less instant read out of Blood, Leucocytes, Nitrite, Specific Gravity, Glucose, Protein, Ketones, Ph , Urobilinogen and Bilirubin. At 43c it really is extraordinary good diagnostic value. Novice clinicians may need to read the manual [above R] - not to be confused with a Pantone colour swatch for matching the curtains with your new dinner-service - but old hands know what key colour change they are looking for. We have Helen Murray Free, and her husband Al, to thank for this now taken-for-granted appropriate technology. 

Helen Murray was born in Pittsburg in 1923 and was all set for an Arts major at college reading English and Latin when Pearl Harbor was bombed and vacancies opened up in blokey science disciplines. Murray switched to Chemistry - if you're smart you can do that - and graduated in 1944 and got a job with Miles Labs in their QC and diagnostics division. But she transferred sideways into the research division run by Al Free and the two of them quickly became a complementary and very effective team. They were tasked to develop new diagnostics for urinary glucose. This was important because there were treatments for diabetes [thank you Banting and Best!], so patients could go forward with hope from a reliable test.

Like a lot of chemical tests, they were looking for a colour change which would light up for glucose and nothing else. Their first products involved soluble pills that could be popped into a urine sample. Clinitest used cupric sulfate, citric acid, sodium hydroxide and carbonate for the fizz. Miles Labs' cornerstone product was Alka-Seltzer so <fizz> was almost required.  But that was wasteful because it needed an extra bottle - the rest of the sample could be used for other diagnostics, sent to a specialist urology lab. Creating another diagnostic test - for Hepatitis A - set the Free lab on a trajectory to make a single product that would do multiple tests at once. Another key conceptual break-through was dry-testing where the active ingredients were migrated to a plastic strip which could be dunked. That saved on the extra bottles and effectively replaced Galen's medieval finger-tip. And the idea could be scaled up to make multiple tests from one product. All sorts of teething problems had to be confronted and solved: separating the various chemical cocktails so they didn't bleed into each other; ensuring stable shelf life. Of all the one-time use plastic products which are available, pee-sticks have arguably the best utility:carbon-footprint ratio.

Helen Murray Free [interview] continued working through six children; co- wrote The Book Urinalysis in Laboratory Practice with Al and retired in 1982 before she turned 60. She then devoted the next few decades to making chemistry understandable and accessible to girls and other groups normally excluded from the Joy of Science. She won the National Medal of Technology & Innovation in 2009. She died in the fullness of her years last Saturday having made a difference.

More Women in Science

Thursday, 6 May 2021

lol internet

How do you identify? I have recently embraced being An Old, but I don't tbh click heels with delight at being a grandparent, although many do, who can. For all my adult years I've considered myself to be EUropean even when [1973-1993] I was strictly EECropean. That was from an ambivalent attitude to the count[r]y where I was born and which I left at the age of 19.  My current book has given me a new sense of identity - as well as being An Old, I am Old Internet; note to self - get a badge made.

Dau.II put me on to Gretchen McCulloch [R], Lauren Gawne and Lingthusiasm, their chatty, fun informative podcast getting enthusiastic about linguistics. Working through four years of back-catalogue, there have been references to Because Internet, Gretchen McCulloch's book on "Understanding the New Rules of Language". I was surprise and delight when I saw that the book was available on the Borrowbox's patchy and eccentric catalogue of audiobooks. Old Internet People [meeeee!] were there before pretty much everyone else. I was using the internet reg'lar for ten years before Tim Berners-Lee invented the WWW. I created an WWW-server and wrote an early Irish website using hand-cranked HTML. I spent rather tooo long, on company time, making 8px x 8px .jpg icons for the ToC for embnet.news, the newsletter of the EUQuango of which INCBI was the Irish node. McCulloch identifies another cohort of Pre-Internet People; these are people of my age who ignored the internet for the longest possible time. These old buffers are really likely to identify as grandparents because they came aboard only/mainly to see photos of distant grandchilder and <ooo frisson> occasionally Skype them.

Another key question for binning the demographics is "did you embrace the internet before or after your parents". Teens keep shifting the territory on which they communicate - Bebo, Facebook, Insta, Tiktok at least partly to be in another room than their parents. Comparing, flirting, checking, nattering are just about impossible if Mum can overhear. Why, it's almost as mortifyin' as knowing your parents have sex. McCulloch is a scholar and a linguist. She's interested in how language is used; like many linguists she's a descriptivist rather than a judgmental proscriptivist. And the internet provides a huge, already transcribed archive of how actual real people talk with each other. This is different from the language used when a linguist is among them taking notes, or when they are writing an essay for school.

When Pat the Salt retired 30 years ago he had a kitchen table with a distant view of the sea and a manual typewriter about the same age as himself. He set about writing stories about his life and times in Africa. Wanari the Salt-trader is wonderfully evocative of a different place and time. Like The Blob, Pat's typings became a daily stream of consciousness tale of events real and imagined concerning people he'd known back in the day. Salty tales of Mountbatten of Burma, whom Pat met in Nigeria in 1965, and his champagne lunches with an androgynous tennis-coach. The magnum opus filled many many xerox boxes of recycled paper. Slightly more than strictly necessary because Pat would . . . use . . . ellipsis . . . to space . . . his thoughts. This form of punctuation is, according to Gretchen McCulloch, widespread in some arenas of the internet. It indicates a chummy informality, partly because it is transgressive of the punctuation rules learned in school. McCulloch traces the habit back to another era and another medium - PostCards - and has analysed a database of hundreds of PCs sent to Ringo Starr in the 1950s and 1960s. 

Informal comms tell us far more about who we are, what we care about, who we care about, than any of the newspapers of record, formal biographies and stately histories with which librarians like to fill their shelves. 

My audiobook of Because Internet is read by the author which is good. As a media commentator with a good ear, she is acutely aware of the medium and has explicitly acknowledged that the spoken word has additional facility for conveying meaning [tone, timbre, emPHASis] which aren't possible in print. BUT it is less easy to catch some important nuances of internet comms: Capitalisation is one example; lol is not the same as LOL. Using the uc/lc conventions of your peers is an important gauge for whether your interlocutor is one of us. McCulloch makes several concessions to make the audio-book a separate product to the dead-tree version. My audio"reader" has a speed button where you can make the voice go 1.25x or even 3.0x faster than it was dictated. That's great if your return deadline looms and you want to finish the book. I might recommend listening to Because Internet at 0.75x speed because nobody would accuse McCulloch of speaking a languid Southern drawl. However, in whatever medium, at whatever speed, read this book, it explains so much about current discourse.


Wednesday, 5 May 2021

Perfidious Albion

I have an old friend who was a commercial lawyer in London who was the World's best negotiator when it came to buying and selling airports and powers-stations. Heck, somebody has to do it and you might as well give the business your best effort. Years ago we were comparing notes over a bottle of red and he told me of a recent coup when, after 3 days of hot and heavy negotiations, at 0230hrs on the last possible day to strike a deal, his team added [or subtracted, I forget] a clause in the contract which was worth $1,000,000 [or ¥1,000,000, it doesn't matter] to his company's bottom line. The amount doesn't matter so much as the sense of putting one over on the opposition. I guess it was framed as "Okay okay, we're all tired, we'll give you THIS, if you concede that", and sleep deficit, the need for shower and a glass of orange juice clouded their judgment.

The Brutish Empire, on which the sun never set, was represented on maps of the era as a lot of dark pink territory. In 1930, a wide swatch of pink joined Cape Town and Cairo even if the projected railway between the two never quite materialise. One of the key outcomes of WWI for this project was the gain of Tanganyika from Germany at the treaty of Versailles. On the other side of the continent German Cameroon was partitioned between the victorious British and French; while the protectorate of Togoland was ceded entirely to the French. I'm focusing on Lake Malawi now because my Philips Schoolboy Atlas has revealed another [prev China - Korea - Russia triple point] peculiarity in the borderlines. I can't easily show you the evidence because Africa is a double-page spread and L. Malawi is mostly in the gutter margin. But the map [here R] indicates the scope of the issue. My [British] Atlas shows the border tracking the lakeshore from the Songwe River in the NW all the way down to the border with Mozambique. From there, the border jinks abruptly into the middle of the lake, which is shared between the two countries. 
WTF?! This means that visitors to the resort of Mbamba Bay [Maps] may disport along the beach but need a passport and visa if they choose to swim. Indeed, it's worse than that because, over the last 120 years, a small river has blurfed about 1 hectare [L with red dots added for emphasis]of delta silt out into lake beyond the border.  If we follow the reasoning of SCOTUS wrt the Ellis Island foreshore and landfill, this part of the beach smells decidedly like Malawi. In contrast to Peñón de Vélez de la Gomera, where similar short-term geological events have changed the shoreline in Africa, Malawi has not yet chosen to garrison this outpost of her territory.

Q. Why am I sure about the 120 year timescale?
A. Because the Heligoland–Zanzibar Treaty / Helgoland-Sansibar-Vertrag was signed 1st July 1890.
This treaty ceded two islands central to the political ambitions of the German and British Empires. Helgoland [170 hectares] guards/threatens the entrance to the Kiel Kanal and the posts of Hamburg and Bremen. Zanzibar [250,000 hectares] otoh has a lot of cloves Syzygium aromaticum. The 
disproportionate 1:1000 calculus was recognised at the time: Ex Chancellor Otto von Bismarck characterised it as exchanging trousers for a button. But that was partly to belittle his recent replacement Count Leo von Caprivi. 

At the same table some other details delimited the spheres of influence of these two rival powers. It looks like, which the name of the treaty confirms, both parties were focused on the islands but the British negotiators were playing hard-ball with the small print. Look chaps, we own Heligoland and you want it. Do you even know where this Lake Malawi is? Our natives do a bit of fishing on it. What? not trout fishing my dear fellow . . . it's of no value to us either but we could concede Heligoland for this bit of a lake . . . and Zanzibar and Pemba of course. Shall we break for lunch and sign afterwards? there's a rather fine claret to go with the beef. In due course The Protectorate of Nyasaland became Malawi and Tanganyika became Tanzania [after it merged with Zanzibar!]. But, as we saw with Machias Island and Märket Island these treaties between colonial powers carry a lot of weight. JStor-walled James Mayall 1973 The Malawi-Tanzania Boundary Dispute. The Journal of Modern African Studies , Dec., 1973, Vol. 11, No. 4 611-628 has documentation from 1922-1972 but doesn't add much light.

There's more to come in the story because the Caprivi Strip was also part of the Anglo-German Treaty of 1890 . . . same continent different river.

Tuesday, 4 May 2021

The cobbler's children

My current fave philosopher is Julia Galef. Here she is posing a poser: why aren't ethicists ethical? It's only 5 minutes long; and that's about the median time I will devote to randutainment from youtube. Galef's answer is to do with the telescope effect: moral philosophers get overwhelmed by the scope of their field [How to be Good is bigger than not beating your children] they they are unable to tune their moral compass effectively. Me, I'm meh - ethicists are jest folks, no better no worse than the rest of us.

But it may be that professional ethicists were top of the class at college in the Arts Block; and they had for sure been top of the class in high-school. They have accordingly been groomed and coddled by parents teachers and peers as being a cut above the rest of us . . . so the rules don't apply to them. That argument probably held true for doctors who continued to smoke for decades after the data came in that smoking upped the odds for cancer, COPD, emphysema, coronaries. And it wasn't just numbers in the BMJ: those same GPs were referring their coughing patients up the medical food chain for drugs, surgery, chemo and an early death.

My lifetime experience of working in science is that it is for sure not the selfless pursuit of objective truth. It is to be expected that successful scientists /anyones are ambitious, hard-working and competitive. What's a bit more disturbing is how invested they are in their own theories / research agendas. We should be resolutely testing our hypotheses; rather than consciously or unc. looking for evidence that will bolster our pre-conceptions. The pressure on researchers to deliver, and deliver on a [funding] timescale, has led too many to finagle their results to get a paper out. PIs, who are ultimately responsible for what the lab turns out, too often get caught in the cycle of enthusiasm for the 'right' result. You may bet your sweet bippy that more fibs work their way into the literature than are caught by RetractionWatch.

If you missed the shoe-making connexion implied by the title, the full proverb is "the cobbler's children have no shoes" . . . because daddy works all day to put food on the table and is too tired when he comes home to count toes under the table. Every person, very organization has to do some self-care or there won't be nothing to give.

Monday, 3 May 2021

Lorra croissants

Borrowbox, the audiobook lending service, is rather patchy in what it makes available. But that's a good thing because it forces me to choose outside of the comfort bubble and perhaps be happily surprised. For example, I'm not really a foodie person and deplore the number of cookbooks which we have at home unopened from one year's end to the next. Elizabeth David's [bloboprev] classics are still worth reading 30 years after her death because she'd been there, done that in the 1940s and had something to say from her lived experience. Felicity Cloake writes a foodie column for the Guardian which Dau.II reads for fun and information, so I've heard of her. And I thought the cover was interesting . . . so I reserved and downloaded the tale of her road-trip round France in pursuit of the perfick croissant [R]. As you can tell from the bottom right corner of the illustration, this [2,000km] road-trip was largely carried out on a bicycle; with some train-connexions to skip the boring bits. Actually I think Cloake and I would agree that there are no boring bits in rural France and she was regularly surprised by the quality of croissant, lunch or dinner in really quite unprepossessing relais & roadhouses. 

The conceit was that she'd sample croissants across the land for buttery, crispy, puffy, deliciousness and give each one a mark out of /10. There were some dire 3/10s on the journey and only two 9.5s. But neither man nor woman can live on croissant alone and Cloake draws on her extensive network of francophone gourmands to secure reservations at a series of fancy restaurants to pitch for The Best examples of the classics of French cuisine: boeuf bourguignon; tarte tatin; tartiflette; poule au pot. So much reduced stock, so much double cream, so half bottles of rouge; so much butter. Working up an appetite converting your flabby London calves into knotted whip-cord is the perfect antidote to this coronary-inducing rich fare. One of the joys of France is that plonk is so cheap you don't have to think twice about adding a generous glug to the cooking.

I don't think recipes do as well in audio as on a page but, like Elizabeth David, the recipes are embedded in the terroir full of options so sound adventurous and empowering rather than depressingly proscriptive. My experience in the kitchen is that you have quite wide leeway in quantities and ingredients before you construct something that is inedible. Recipes that convert 1oz to 28.5 g rather 30g are probably not written by a cook.

There's a lovely moment right at the end of the book, when Cloake and Eddie Merckx, her sturdy wheels, arrange to meet a pal with chanpagne under L'Arc de Triomphe in the middle of Paris. Having been told off for a) having a bicycle b) swigging bubbly under a war memorial, she is approached by two gendarmes. But rather than giving her a further wigging, the two lads are just interested in the bike and the journey. Full of admiration, the younger cop steps back and raises his cap: "Chapeau, Madame!" Formidable and, like, Ouf!

Sunday, 2 May 2021

Mayday m'aidez

Mayday yest. Bank holiday tomo