Which brings us to Careblazers TV which was founded Dr. Natali, a board certified geropsychologist, so no more a Doctor than PhD-me is a Doctor. It's a youtube channel which gives help and supportive advice to carers-of-elders. In many cases, this acknowledges that the Elders are beyond caring much about anything. Here's one vid on dementia meds [36mins] which I found useful because it explained a bit about the classes of drugs, their mode of action, and something about their interactions. Without that you're just presented with a blizzard of damn-fool names: some proprietary, some me-too generics, some equivalent, some completely different; some Pfizer, some Glaxo. The information is delivered easy as a dialogue between Dr Natali and
- Acetylcholinesterase inhibitors
- Acetylcholine ACh is a neurotransmitter
- Acetylcholinesterase is an enzyme which breaks down ACh after it has made its run
- An ACh inhbitor therefore allows more ACh to hang around in the synapses of the brain keeping them active and firing when they're tired and would rather have a nice lie down.
- Aricept - Galantamine - Exelon: these are all Trade-names not pharmacy names although the latter are equally random coinages.
- Recommended for early / medium stage dementia. Does nothing for the progression of the disease but at least makes modest improvements in the symptoms
- NMDA inhibitors
- NMDA is an artificial analogue of glutamate.
- Glutamate, as well as being an amino acid found in all proteins, acts as a gee-up neurotransmitter.
- Too much glutamate / NMDA and the brain gets over-stimulated and bursts out in anger, psychosis and other difficult-to-care-for dementia symptoms
- Overstimulation can also result in cell-death (it's like blowing a cylinder-head gasket) and the result holes on the brain lead to memory loss etc.
- Inhibit the neurotransmitters NT and hope that everything calms down.
- Namenda is the trade-name
- Advised for later when beloved elder is beyond help from Aricept.
- And of course you can buy the double whammy with both drugs in one pill
- That would be Namzaric.
Side effects: Diarrhea, nausea, vomiting, loss of appetite, increased weight, loss of bladder control, back pain, headache, bruising, drowsiness, or dizziness may occur. No surprises here: AcetylCholine is a one multi-tasking neurotransmitter triggers muscular contraction [bladder sphincter included] and a host of other systems and functions in the body.
captured and tweeted [see L] one way of allaying suspicion and worry in one of his elderly patients. It went viral and was a lot cheaper and less intrusive than a pharmaceutical solution.